|
KMID : 0363320030240010055
|
|
Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.55 ~ p.67
|
|
|
Protective effects of Jucha-whan on liver injury of guinea pigs induced by CCl_4 and d-galactosamine
|
|
Choi Eun-Ju
Kang Jae-Chun
|
|
|
Abstract
|
|
|
Objective : In order to investigate the curative effect of Jucha-whan on the protective liver of guinea pigs induced by CCl_4 and d-galactosamine, serum transaminase(GOT, GPT), lactic dehydrogenase(LDH), alkaline phosphatase(ALP), glutathione S-transferase(GST), superoxide dismutase(SOD) were used to measure enzyme activities and lipid peroxide level.
Method : The subject animals were divided into 5 groups; a control group(untreated), a subject group(administered with 0.9% Saline solution), a sample I (500mg/kg administered), sample II group (1000mg/kg administered), positive control group(administered with 200mg/kg silymarine).
Result : The inhibitory effects on the serum GOT, LDH, ALP, SOD and Lipid peroxide level activities in protective liver of mice induced by CCl_4 were noted both in the sample I group and sample II. The inhibitory effects on the serum GPT activities in protective liver of guinea pigs induced by CCl_4 were noted in sample II group, but it was not noted in the sample I. The inhibitory effects on the GST activities in protective liver of guinea pigs induced by CCl_4 were not noted in both sample I and sample group II. The inhibitory effects on the serum GOT, GPT activities in protective liver of guinea pigs induced by d-galactosamine were noted in both sample I and sample II, but it was not recognizable statistically. The inhibitory effects on the serum LDH activities in protective liver of guinea pigs induced by d-galactosamine were noted in sample II, but it was not noted in sample I group.
Conclusion : According to the above results, it is considered that Jucha-whan has treatment effects on liver injury in guinea pigs induced by CCl_4 and d-galactosamine. So it is required to study about the actions of mutual relation of medicines and patho-mechanism through experiment.
|
|
|
KEYWORD
|
|
|
Jucha-whan, CCl_4
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|